Dr Carl Hartman – Credentials, Associations, Research

Refractive Surgery Credentials

  • Actively performing refractive surgery since entering practice in 1990
  • Lecturer and Instructor for Multiple Refractive Surgery Seminars
  • Ophthalmology Residency with training in Corneal Transplantation, under Chairman Richard Keates, M.D.
  • Corneal Transplantation and Refractive Surgery Techniques, Max Fine, M.D.
  • Corneal and Refractive Surgery Course, Herbert Kaufman, M.D.
  • Radial and Astigmatic Keratotomy Certification, American Academy of Ophthalmology
  • Keratorefractive Surgery and Certification, Miles Friedlander, M.D.
  • Advanced Refractive Surgery and Astigmatism Update and Recertification in Modern Refractive Surgery Techniques, Lee Nordan, M.D.
  • VISX University Excimer Laser System Certification
  • VISX CustomVue Laser Correction Certification
  • Phacorefractive Surgery, The Barnet Dulaney Eye Foundation
  • Corneal Topography and Refractive Surgery Update, Beckman Laser Institute at University of California, Irvine
  • Advanced Corneal Topography, American Academy of Ophthalmology
  • Advanced Refractive Keratoplasty, American Academy of Ophthalmology
  • C-LASIK: Lamellar Refractive Surgery Certification, Stephen G. Slade, M.D.
  • LASIK and Hansatome Certification, Stephen G. Slade, M.D.
  • NIDEK Excimer Laser Certification
  • IntraLASIK Certification, Intralase Corporation
  • Wavefront CustomVue Certification, VISX Corporation
  • VISX Fourier Wavefront Certification, VISX Corporation
  • CustomVue Hyperopia and Hyperopic Astigmatism Certification, VISX Corporation
  • Certified Refractive Surgeon, Council for Refractive Surgery Quality Assurance Certification (CRSQA)
  • Z-LASIK Femtosecond Certification, Zeimer Corporation
  • Wavelight Allegretto Wave Eye-Q Laser Certification, Alcon Corporation
  • LenSx Certification, Alcon Corporation
  • ORA Certification, Alcon Corporation
  • Light Adjustable Lens Certification, RxSight Corporation
  • Ongoing continuing education courses, recertifications, academic meetings, and attendance

Professional Associations

  • Fellow of the American Academy of Ophthalmology
  • Fellow of the American College of Surgeons
  • American Society of Corneal and Refractive Surgery
  • Refractive Surgery Interest Group – American Academy of Ophthalmology
  • International Society of Refractive Surgery
  • Phi Delta Epsilon Medical Fraternity – President, Beta Tau Chapter, 1984-1985
  • Los Angeles County Medical Association
  • Long Beach Medical Association
  • California Medical Association
  • American Medical Association
  • Orange County Society of Ophthalmology
  • Orange County Medical Association

Research

  • Principal Investigator—Collection of excised chalazia for PCR based quantitation of Demodex species (SPP) TRS-031
  • Sub-Investigator—A prospective, multicenter, open label, single arm, post-marketing clinical study to evaluate real world outcomes of the enVista®Aspire (EA) and Apire Toric (ETA) intraocular lens in subjects undergoing cataract extraction.

  • Sub -Investigator—A pilot, double-masked, vehicle controlled, randomized study to evaluate the safety and tolerability of QLS-111 versus vehicle in combination with Latanoprost treatment in subjects with open angle glaucoma and /or ocular hypertension (Apteryx).

  • Sub-Investigator– A vehicle controlled, multi-site, double masked study to evaluate the safety and tolerability of QLS-111 versus vehicle in subjects with primary open-angle glaucoma or ocular hypertension (Osprey).
  • Sub-Investigator—A phase IV: Randomized controlled trial to evaluate the impact of XDEMVY™ on Demodex Blepharitis in soft contact lens wearers (Ariel).
  • Sub-Investigator—A phase 3, Prospective, double-masked, vehicle controlled, parallel group, 12 -week administration ad 40-week extension study confirming the efficacy and safety of K-161 ophthalmic solution for the treatment of moderate to severe Dry Eye Disease.
  • Principal Investigator—A Clinical Investigation of the Tecnis® Next-Generation Intraocular Lens, Model DEN00V.
  • Principal-Investigator—A clinical Investigation of the Bacterially-Derived Healon EndoCoat Pro Ophthalmic Viscosurgical Device (OVD) VSCO-110-LOKE.
  • Sub-Investigator — A Phase 2, Multi-center, double-masked, randomized, vehicle controlled, dose response, parallel group study of SY-201 Ophthalmic Solution versus Vehicle control in subjects with dry eye disease.
  • Sub-Investigator — A Double-Masked, Randomized, Placebo-Controlled, Parallel-Group, 12-Week treatment and 14-week extension, Phase 3 Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery.
  • Sub-Investigator – A phase 2, multicenter, double masked, randomized, vehicle controlled clinical trial evaluating the safety, tolerability and efficacy of A197 in subjects with Dry Eye Disease.
  • Sub-Investigator — A phase 2 Study to determine safety and efficacy of the investigational new drug TTHX1114 (NM141) on the regeneration and migration of Corneal Endothelial Cells in patients undergoing Descemetorhexis without Endothelial Keratoplasty (Descemet Stripping Only).
  • Principal Investigator — Clinical Evaluation of the vision performance of Tecnis Eyhance™ intraocular lenses with Tecnis Simplicity™ as compared to Tecnis® 1-piece intraocular lenses.  EMON-101-EHCE.
  • Sub-Investigator — A Phase 2b/3, Randomized, Double-Masked, Vehicle-Controlled Study Evaluating the Safety and Efficacy of Two Concentrations (0.4% and 1%) of ALY688 Ophthalmic Solution in Subjects with Dry Eye Disease (OASIS-1).
  • Sub-Investigator — A phase 2a, double-masked, randomized vehicle-controlled trial evaluating the safety and efficacy activity of 1% and 5% VVN001 compared to vehicle in subjects with Dry Eye Disease (VVN001-CS-201).
  • Sub-Investigator – A multicenter, randomized, double-masked, placebo controlled, parallel group study to evaluate the efficacy and safety of APP13007 for the treatment of inflammation and pain after cataract surgery.
  • Sub- Investigator—A phase 3, randomized, adaptive dose selection, multi-regional, double masked, parallel group, 3-month trial evaluating the safety and efficacy of NCX 470 Vs. Latanoprost 0.005% in subjects with open angle glaucoma or ocular hypertension (Mont Blanc).
  • Sub-Investigator—A Phase III Multi-Center open label, single arm extension clinical trial to assess the extended long-term safety and tolerability of NOV03 (Perflurohexyloctane) in subjects who completed trial NVU-003 (SEECASE-2 OLE).
  • Sub-Investigator – A Phase II/III, randomized, double masked, Vehicle controlled study for the safety, tolerability and efficacy of AXR-270 topical eyelid cream in treating posterior blepharitis associated with Meibomian gland dysfunction.
  • Sub-Investigator — A phase 3, multi-center, randomized, double masked, Saline controlled trial to evaluate the effect of NOV03 (Perfluorohexyloctane) on signs and symptoms of Dry-Eye disease associated with Meibomian gland dysfunction (SEECASE-2).
  • Sub-Investigator – A multicenter, double masked, randomized, vehicle-controlled study of the efficacy and safety of HY02 ointment in subjects with Inflamed Meibomian Gland Dysfunction.
  • Sub-Investigator – A phase 3, double masked, randomized controlled study of KPI-121 0.25% Ophthalmic Suspension compared to vehicle in subjects with Dry Eye Disease (STRIDE 3).
  • Principal Investigator – Post-Approval Study of the TECNIS Symfony® Toric Lenses.
  • Sub-Investigator – A double-masked, multicenter, placebo-controlled, parallel-group study to assess the efficacy of SJP-0035 0.001% for the treatment of patients with dry eye disease (Delta-1 study).
  • Sub-Investigator—A randomized, multicenter, double masked, placebo controlled, parallel group, bioequivalence study to evaluate the clinical equivalence and safety of Nepafenac 0.3% Ophthalmic suspension (manufactured by Inoco remedies Ltd. For Actavis LLC) with Ilevro™ (Nepafenac ophthalmic suspension), 0.3% of Alcon Laboratories, Inc, for the treatment of pain and inflammation associated with cataract surgery.
  • Investigator- The Leadership 301Trial: a 12-week randomized, multicenter, double-blind placebo controlled, 3-arm, parallel group, phase 3 trial to evaluate the efficacy and safety of 2 doses of AQX-1125 targeting SHIP1 pathway in subjects with interstitial cystitis/bladder pain syndrome followed by an extension period. Aquinox Pharmaceuticals (Canada) Inc.
  • Principal Investigator – A Multicenter, double masked, randomized, placebo-controlled evaluation of the safety and efficacy of SUN-131 Transdermal System (TDS) as compared to placebo TDS in patients with Chalazion.
  • Principal Investigator – Post-Approval study of the TECNIS® Toric IOL Extended Cylinder Range (ECR), Models ZCT450, ZCT525 and ZCT600. 2017.
  • Sub-investigator- A double masked, randomized, multicenter, placebo controlled, parallel group study of SJP-0035 Ophthalmic Solution compared with placebo to assess safety and efficacy of two dose concentrations of SJP-0035 Ophthalmic Solution for Corneal Epithelial Wound Healing in patients with moderate to severe Corneal Epithelial Disorders. 2017
  • Sub investigator- A Phase 3, multicenter, double masked, vehicle controlled, randomized, parallel-group study to asses Loteprednol Etabonate Ophthalmic Gel, 0.38% (BID and TID) versus Vehicle Gel for the treatment of ocular inflammation and pain following Cataract surgery. 2017
  • Sub investigator- A prospective, multicenter, randomized, parallel-arm, double masked, vehicle-controlled phase 3a study, evaluating the safety and efficacy of OTX-TP in the treatment of subjects with open angle glaucoma or ocular hypertension. 2016 – 2017
  • Principal Investigator- Post – Approval study of the Tecnis® Toric IOL, models ZCT 300 and ZCT 400.
  •  Principal Investigator- A double masked, randomized, multicenter, active controlled, parallel group, 6-month study with a 3-month interim analysis assessing the ocular hypotensive efficacy and safety of AR-13324 ophthalmic solution, 0.02% QD compared to Timolol Maleate ophthalmic solution, 0.5% BID in patients with elevated intraocular pressure (ROCKET- 4),2016
  • Sub investigator- A multicenter, randomized, double-masked, active controlled study to evaluate the safety and efficacy of LME636 in patients with Acute Anterior Uveitis, 2015 – 2016
  • Principal Investigator-A double-masked, randomized, multi-center, active controlled, parallel, 3-month study assessing the safety and ocular hypotensive efficacy of AR-13324 Ophthalmic Solution, 0.02% compared to Timolol Maleate Ophthalmic Solution, 0.5% in patients with elevated intraocular pressure. Rho-Kinase Elevated Intraocular Pressure Treatment Trial (ROCKET-1), 2014 – 2015
  • Principal Investigator-Icon Bioscience C13-04 Phase 3 prospective, randomized, double masked,

    placebo controlled, parallel al design multicenter study to evaluate the efficacy and safety of 1B110090 for the treatment of inflammation associated with Cataract surgery, 2014

  • Principal Investigator- Visiogen Study SYNC-601-IOL: A prospective multicenter clinical study to evaluate the safety and effectiveness of Synchrony dual optic intraocular lens in patients undergoing cataract extraction (Phase 1), 2009
  • Principal Investigator- Visiogen Study SYNC-601-IOL: A prospective multicenter clinical study to evaluate the safety and effectiveness of Synchrony dual optic intraocular lens in patients undergoing cataract extraction (Phase 2)
  • Sub investigator- Study AZ04; Collaborative Neuroscience
  • Sub investigator- Study DSP; Collaborative Neuroscience
  • Sub investigator- Study Seroquel D1443-C0040; Collaborative Neuroscience
  • Sub investigator- Lens Opacification Classification System III; Forest II study; CNS
  • Sub investigator- Lens Opacification
  • Classification System III; Forest 36 study; CNS
  • Clinical Investigator: Ophthalmologic effects of Interferon in treating Hepatitis C, 2003
  • Clinical Investigator: Allergan, Inc. – Efficacy of Bimatoprost (lumigan) in lowering intraocular pressure in chronic open angle glaucoma, 2002

  • Clinical Investigator: Pharmacia – 920 Silicone Foldable Intraocular Lens in Small Incision Cataract Surgery 1998
  • In vitro study of “Incisional Refractive Surgery using Investigational Endothelial Microscopy Guided Diamond Knife” 1996
  • Computerized Vector Analysis of Corneal Astigmatism Based on Surgical Technique 1996
  • Clinical Investigator Chiron Ophthalmics Collagen Shields in Ophthalmic Surgery 1992
  • Ophthalmologic Examiner grading Cataract Formation Secondary to usage of FDA investigational Cholesterol Lowering Medication 1990
  • Clinical Investigator for trials of “Cytomegalovirus Retinopathy Suppression in AIDS Patients using Gancyclovir (DHPG)” University of California, Irvine 1989
  • “Leukemic infiltration of the optic nerve head” 1988
  • “Fluorophotometric comparison of tear flow and corneal permeability in keratoconjunctivitis sicca and normal subjects” Presented at ARVO 1987
  • University of California Irvine “Quantitative conjunctival impression cytology in diseases of mucin deficiency” Presented at ARVO 1985
  • University of Southern California Institute of Marine & Coastal Studies Catalina, CA “Underwater studies using SCUBA of the subtidal flora & fauna interactions” 1977-1978

Staff Surgical Privileges

  • UCI Health, Lakewood – Active
  • UCI Health, Los Alamitos – Active
  • Lakewood Eye Physicians SurgiCenter – Active
  • SoCal Eye Eye Laser Center – Active
  • Memorial Care Surgery Center – Active
  • Reagan Street Surgery Center – Active
  • University of California Irvine Medical Center – Consultant
  • Long Beach Veterans Hospital – Consultant

Elected Positions & Committees

  • Chief of Staff, Lakewood Regional Medical Center
  • Vice Chief of Staff, Lakewood Regional Medical Center
  • Chairman – Department of Surgery, Lakewood Regional Medical Center
  • Medical Executive Committee, Lakewood Regional Medical Center
  • Medical Executive Committee, Los Alamitos Medical Center
  • Governing Board, Lakewood Regional Medical Center
  • Chairman – Operating Room Operations Committee, Lakewood Regional Medical Center
  • Chairman – Credentials, Lakewood Regional Medical Center
  • Chairman – Bylaws Committee – UCI Health, Lakewood
  • Chairman – Utilization Review / Medical Records, Lakewood Regional Medical Center
  • Patient Safety Committee, Los Alamitos Medical Center
  • Bylaws Committee, Long Beach Memorial Medical Center
  • Utilization Review, Lakewood Health Plan
  • Utilization Review, Long Beach Memorial IPA
  • Chairman – Credentials, Lakewood Eye Physicians SurgiCenter
  • Utilization Review, Community Care Network
  • Board of Directors, Lakewood Physicians Association
  • Program Director, Orange County Medical Association/ University of California, Irvine Student Shadowing Program
  • Director and Founder – UCI Shadowing Program

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